Bacterial Growth in Platelet Concentrates Despite Gamma Irradiation
نویسندگان
چکیده
منابع مشابه
pH changes caused by bacterial growth in contaminated platelet concentrates.
While platelet concentrates are stored at room temperature, lactic and other acids are produced and the pH decreases as the buffering capacity of the plasma is exhausted. Platelet viability will be compromised if the pH decreases to pH 6.0 and below. Similarly, a pH decrease can be produced also by bacterial contamination if the organisms produce acid as an end product. Thus the determination o...
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Besides the current efforts devoted to microbial risk reduction, pathogen inactivation technologies promise reduction of the residual risk of known and emerging infectious agents. A novel pathogen reduction process for platelets, the THERAFLEX UV-Platelets system, has been developed and is under clinical evaluation for its efficacy and safety. In addition, proof of principle has been shown for ...
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BACKGROUND During the transfusion of blood components, the transfer of allogeneic donor white blood cells (WBCs) can mediate transfusion-associated graft-versus-host disease (TA-GVHD). To minimize the reaction, exposure of blood products to gamma irradiation is currently the standard of care. The aim of our study was to evaluate and compare hemostatic function, transfusion efficacy, and safety ...
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(unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request pe...
متن کاملBacterial contamination of platelet concentrates: pathogen detection and inactivation methods
Whereas the reduction of transfusion related viral transmission has been a priority during the last decade, bacterial infection transmitted by transfusion still remains associated to a high morbidity and mortality, and constitutes the most frequent infectious risk of transfusion. This problem especially concerns platelet concentrates because of their favorable bacterial growth conditions. This ...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 1999
ISSN: 0002-9173,1943-7722
DOI: 10.1093/ajcp/111.1.137